Publication details

Utilization of LA-ICP-MS for bioimaging

Authors

VACULOVIČ Tomáš TVRDOŇOVÁ Michaela MASAŘÍK Michal POLANSKÁ Hana SVOBODOVÁ Markéta GUMULEC Jaromír KANICKÝ Viktor ČADKOVÁ Zuzana OTRUBA Vítězslav SZÁKOVÁ Jiřina

Year of publication 2016
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Science

Citation
Description Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) represents one of the most suitable method for study of lateral distribution of specific elements (Cu, Zn, Pb, Pt...) in low concentration levels (tens mg/kg) in various biological tissues. Presented work is focused on study of influence of scan speed and laser spot diameter on lateral resolution, LOD, and time consumption of analysis. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on two different types of the matrices. First one is tumour tissue which is treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt). The second one are cuts of tapeworm treated by various heavy metals.
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