Publication details

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

Authors

MIKALOVÁ Lenka STROUHAL Michal OPPELT Jan GRANGE Philippe Alain JANIER Michel BENHADDOU Nadjet DUPIN Nicolas ŠMAJS David

Year of publication 2017
Type Article in Periodical
Magazine / Source PLoS neglected tropical diseases
MU Faculty or unit

Faculty of Medicine

Citation
Web http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
Doi http://dx.doi.org/10.1371/journal.pntd.0005434
Field Epidemiology, infectious diseases and clinical immunology
Keywords Treponema pallidum
Description The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
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