Publication details
Modulation of neutrophil oxidative burst via histamine receptors
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | British Journal of Pharmacology |
| Citation | |
| Doi | http://dx.doi.org/10.1111/bph.12107 |
| Keywords | neutrophil; oxidative burst; reactive oxygen species; histamine; histamine receptor |
| Description | Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H-1 and H-2 receptors in this process is discussed and compared to that of the recently discovered H-4 receptor. |