Publication details

Interleukin-17A gene variant and allergic asthma in the Czech population

Authors

NOVÁK David BOŘILOVÁ LINHARTOVÁ Petra IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2017
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Objectives: Allergic asthma is a chronic multifactorial disease of the lower respiratory tract, which pathogenesis is typically described using the Th1/Th2 paradigm. However, with the discovery of Th17 lymphocytes, this paradigm has to be revised: IL-17 was revealed to play a role in several autoimmune diseases previously considered to be caused by the imbalance of Th1 and allergic responses. We investigated a possible connection between IL-17A gene variant and allergic asthma in the Czech population. Methods: A total of 621 subjects were included in this case-control study: 294 healthy controls and 327 patients with history of allergic asthma. Clinical examination was performed, IgE levels were determined and a skin-prick test to assess the reactivity for various allergens was evaluated in a subgroup of patients. All the subjects were genotyped for IL-17A single nucleotide polymorphism (SNP) rs2275913 by qPCR method with TaqMan fluorescent assays. Results: While no significant differences in allele or genotype frequencies of IL-17A SNP rs2275913 between healthy controls and patients with asthma were found (P>0.05), a significant association between G allele and GG genotype and a reactivity to dog dander was observed (P<0.01). Conclusions: Although no effect of IL-17A SNP rs2275913 on asthma development in the Czech population was found, carriers of G base in this polymorphic site may be protected against dog allergy.
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