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Interleukin-17A gene variant and allergic asthma in the Czech population

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NOVÁK David BOŘILOVÁ LINHARTOVÁ Petra IZAKOVIČOVÁ HOLLÁ Lydie

Rok publikování 2017
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Objectives: Allergic asthma is a chronic multifactorial disease of the lower respiratory tract, which pathogenesis is typically described using the Th1/Th2 paradigm. However, with the discovery of Th17 lymphocytes, this paradigm has to be revised: IL-17 was revealed to play a role in several autoimmune diseases previously considered to be caused by the imbalance of Th1 and allergic responses. We investigated a possible connection between IL-17A gene variant and allergic asthma in the Czech population. Methods: A total of 621 subjects were included in this case-control study: 294 healthy controls and 327 patients with history of allergic asthma. Clinical examination was performed, IgE levels were determined and a skin-prick test to assess the reactivity for various allergens was evaluated in a subgroup of patients. All the subjects were genotyped for IL-17A single nucleotide polymorphism (SNP) rs2275913 by qPCR method with TaqMan fluorescent assays. Results: While no significant differences in allele or genotype frequencies of IL-17A SNP rs2275913 between healthy controls and patients with asthma were found (P>0.05), a significant association between G allele and GG genotype and a reactivity to dog dander was observed (P<0.01). Conclusions: Although no effect of IL-17A SNP rs2275913 on asthma development in the Czech population was found, carriers of G base in this polymorphic site may be protected against dog allergy.
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