Publication details

3D Cell Culture: An Introduction

Authors

KOLEDOVÁ Zuzana

Type Article in Proceedings
Conference 3D Cell Culture : Methods and Protocols
MU Faculty or unit

Faculty of Medicine

Citation
WWW https://link.springer.com/protocol/10.1007%2F978-1-4939-7021-6_1
Doi http://dx.doi.org/10.1007/978-1-4939-7021-6_1
Field Genetics and molecular biology
Keywords 3D cell culture; Bioprinting; Extracellular matrix; Microenvironment; Microfluidics; Spheroid; Tissue architecture
Description 3D cell culture is an invaluable tool in developmental, cell, and cancer biology. By mimicking crucial features of in vivo environment, including cell–cell and cell–extracellular matrix interactions, 3D cell culture enables proper structural architecture and differentiated function of normal tissues or tumors in vitro. Thereby 3D cell culture realistically models in vivo tissue conditions and processes, and provides in vivo like responses. Since its early days in the 1970s, 3D cell culture has revealed important insights into mechanisms of tissue homeostasis and cancer, and accelerated translational research in cancer biology and tissue engineering
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