Informace o publikaci

3D Cell Culture: An Introduction



Druh Článek ve sborníku
Konference 3D Cell Culture : Methods and Protocols
Fakulta / Pracoviště MU

Lékařská fakulta

Obor Genetika a molekulární biologie
Klíčová slova 3D cell culture; Bioprinting; Extracellular matrix; Microenvironment; Microfluidics; Spheroid; Tissue architecture
Popis 3D cell culture is an invaluable tool in developmental, cell, and cancer biology. By mimicking crucial features of in vivo environment, including cell–cell and cell–extracellular matrix interactions, 3D cell culture enables proper structural architecture and differentiated function of normal tissues or tumors in vitro. Thereby 3D cell culture realistically models in vivo tissue conditions and processes, and provides in vivo like responses. Since its early days in the 1970s, 3D cell culture has revealed important insights into mechanisms of tissue homeostasis and cancer, and accelerated translational research in cancer biology and tissue engineering
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