Publication details

Looking for inhibitor: structural and functional analysis of novel bangle lectin PHL from Photorhabdus asymbiotica

Authors

HOUSER Josef JANČAŘÍKOVÁ Gita DOBEŠ Pavel FUJDIAROVÁ Eva HYRŠL Pavel CSÁVÁS Magdolna MORAVCOVÁ Jitka WIMMEROVÁ Michaela

Year of publication 2018
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Description In Photorhabdus asymbiotica genom, we identified a gene for a putative lectin, and examined the corresponding recombinant protein PHL from functional and structural point of view. We succeeded in determining structure of PHL in complex with several monosaccharides and tested a wide range of various mono-, di- and oligovalent carbohydrate-based molecules. Data gained so far show the way for design and synthesis of potential therapeutics.
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