Publication details

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Title in English Ztráta asociace mezi genovým polymorfizmem v ENAM a zubním kazem v dočasné i stálé dentici u českých dětí
Authors

BOŘILOVÁ LINHARTOVÁ Petra DEISSOVÁ Tereza MUSILOVÁ Kristína ŽÁČKOVÁ Lenka KUKLETOVÁ Martina KUKLA Lubomír IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2018
Type Article in Periodical
Magazine / Source Clinical Oral Investigations
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s00784-017-2280-2
Keywords enamelin; gene polymorphism;dental caries;case-control study;primary dentition; permanent dentition
Description Objectives The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. Materials and methods This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft >= 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT >= 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. Results No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. Conclusions Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.
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