Publication details
Plazmidově vázaná rezistence ke kolistinu: hrozba i pro Českou republiku?
| Title in English | Plasmid-mediated colistin resistance: a threat for the Czech Republic? |
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| Authors | |
| Year of publication | 2018 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | Colistin belongs to the polymyxin class of antibiotics and is active against most of Gram-negative bacteria. In veterinary medicine it is used to treat infections caused by bacteria from Enterobactericeae family. Currently, the importance of colistin is returning in treating human infections caused by multidrug-resistant bacteria. The mechanisms of resistance to colistin are encoded chromosomally but the main threat represents recently discovered resistance carried on mobile genetic elements. Plasmids are spread by horizontal transfer inside species but also in between them. The mcr-1 gene was first identified in 2015 in animals in China and since then other cases of bacteria carrying mcr-1 gene and others (mcr-2 to mcr-5) were described throughout the world. The international market with animals and food can be a source of spreading this type of resistance. The occurrence of mcr genes was not yet fully studied in the food chain or in humans in the Czech Republic. In this study the incidence of mcr genes in selected food from retail of the Czech Republic was observed. |