Publication details

SEMIQUANTITATIVE ASSESSMENT OF DISHEVELLED-3 PHOSPHORYLATION STATUS BY MASS SPECTROMETRY

Authors

HANÁKOVÁ Kateřina POTĚŠIL David BERNATÍK Ondřej ČERVENKA Igor RÁDSETOULAL Matěj BRYJA Vítězslav ZDRÁHAL Zbyněk

Year of publication 2018
Type Article in Periodical
Magazine / Source HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY
MU Faculty or unit

Central European Institute of Technology

Citation
Doi http://dx.doi.org/10.1515/hjic-2018-0002
Keywords phosphorylation; Dishevelled 3; mass spectrometry; CK1 epsilon; NEK2
Description The focus of this paper is the human Dishevelled 3 protein (hDvl3), an essential component of the Wnt signalling pathway that contributes to their regulation. Mass spectrometry-based analysis of hDvl3 phosphorylations induced by eight associated kinases was performed revealing several dozens of phosphorylation sites. The main outcome of this study was the description of Dvl phosphorylation "patterns" induced by individual kinases.
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