Publication details
Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Proceedings |
| Conference | SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018 |
| MU Faculty or unit | |
| Citation | |
| Keywords | Sulfate-reducing bacteria; IBD; 8-hydroxyquinoline-2-carboxanilides |
| Description | The increased number of sulfate-reducing bacteria (SRB) and the intense process of dissimilatory sulfate reduction in the gut are thought to be significant risk factors of inflammatory bowel diseases in both humans and animals. These bacteria are often found in persons with rheumatic diseases, ankylosing spondylitis, etc. [1]. There is also an assumption that SRB can be responsible for some forms of cancer of the rectum through the formation of hydrogen sulfide that affects the metabolism of intestinal cells and give rise to various inflammatory bowel diseases [2,3]. Hydroxynaphthalene-2-carboxanilides can be considered as cyclic analogues of salicylanilides that have expressed promising results as potential antimicrobial agents. Their antimicrobial effects are connected with the ability of vicinal hydroxyarylamides to inhibit various enzymatic systems in bacteria. In addition, the presence of an amide group with a hydrophobic residue in its close vicinity is able, due to its electron properties, to interact and bind with a number of enzymes/receptors and affect the biological response by means of these target sites. The properties of the amide moiety can be easily modified by various substitutions [4,5]. In our previous research, antimicrobial effect of salicylamide derivatives against intestinal sulfatereducing bacteria as well as influence of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger were studied and described [6-7]. The present work is focused on investigation of the biological activity of N-alkoxyfenyl-3-hydroxynaftalen-2-carboxamides against intestinal sulfate-reducing bacteria isolated from mice. |