Publication details

ATM and TP53 mutations show mutual exclusivity but distinct clinical impact in mantle cell lymphoma patients

Authors

MAREČKOVÁ Andrea MALČÍKOVÁ Jitka TOM Nikola PÁL Karol RADOVÁ Lenka ŠÁLEK David JANÍKOVÁ Andrea MOULIS Mojmír ŠMARDOVÁ Jana KŘEN Leoš MAYER Jiří TRBUŠEK Martin

Type Article in Periodical
Magazine / Source LEUKEMIA & LYMPHOMA
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1080/10428194.2018.1542144
Doi http://dx.doi.org/10.1080/10428194.2018.1542144
Keywords Mantle cell lymphoma; ATM; TP53; p21; SOX11; survival
Description Mantle cell lymphoma (MCL) is characterized by the hallmark t(11;14)(q13;q32) translocation, leading to cyclin D1 over-expression. Additionally, disrupting the DNA damage response pathway through ATM or TP53 defects plays an important role in MCL pathogenesis. Using deep next-generation sequencing we analyzed the mutual composition of ATM and TP53 mutations in 72 MCL patients, and assessed their impact on progression-free survival (PFS) and overall survival (OS). Mutated ATM and TP53 alleles were found in 51% (37/72) and 22% (16/72) of the cases examined, respectively, with only three patients harboring mutations in both genes. Only a mutated TP53 gene was associated with the significantly reduced PFS and OS and the same output was observed when ATM and TP53 defective groups included also sole deletions 11q and 17p, respectively. Determining the exact ATM/p53 pathway dysfunction may influence the selection of MCL patients for innovative therapies based on the targeted inhibition of selected proteins.
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