Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

• Authors: DRAŽANOVÁ Eva; KRÁTKÁ Lucie; VAŠKOVICOVÁ Naděžda; SKOUPÝ Radim; HORSKÁ Kateřina; BABINSKÁ Zuzana; KOTOLOVÁ Hana; VRLÍKOVÁ Lucie; BUCHTOVÁ marcela; STARČUK Zenon; RUDÁ Jana
• Year of publication: 2019
• Type: Article in Periodical
• Magazine / Source: Pharmacological Reports
• MU Faculty or unit: Faculty of Medicine
• Web: https://www.sciencedirect.com/science/article/pii/S1734114019300714
• Doi: http://dx.doi.org/10.1016/j.pharep.2019.04.020
• Keywords: Arterial Spin Labelling; cortex; leptin; olanzapine; Sprague-Dawley rats
• Description: Both acute and chronic dosing of olanzapine resulted in decreased perfusion in the sensorimotor cortex, while no effect was observed in the piriform cortex or hippocampus. Furthermore, in the chronically treated group decreased cortex volume was observed. Chronic olanzapine dosing led to increased body weight, adipose tissue mass and leptin level, confirming its expected metabolic effects.

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