Publication details

Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

Authors

DRAŽANOVÁ Eva KRÁTKÁ Lucie VAŠKOVICOVÁ Naděžda SKOUPÝ Radim HORSKÁ Kateřina BABINSKÁ Zuzana KOTOLOVÁ Hana VRLÍKOVÁ Lucie BUCHTOVÁ marcela STARČUK Zenon RUDÁ Jana

Type Article in Periodical
Magazine / Source Pharmacological Reports
MU Faculty or unit

Faculty of Medicine

Citation
WWW https://www.sciencedirect.com/science/article/pii/S1734114019300714
Doi http://dx.doi.org/10.1016/j.pharep.2019.04.020
Keywords Arterial Spin Labelling; cortex; leptin; olanzapine; Sprague-Dawley rats
Description Both acute and chronic dosing of olanzapine resulted in decreased perfusion in the sensorimotor cortex, while no effect was observed in the piriform cortex or hippocampus. Furthermore, in the chronically treated group decreased cortex volume was observed. Chronic olanzapine dosing led to increased body weight, adipose tissue mass and leptin level, confirming its expected metabolic effects.
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