Publication details

Efektivní metodika pro stanovení haplogenotypů lektinu vázajícího manózu a role tohoto receptoru v etiopatogenezi onemocnění dutiny ústní

Title in English Effective methodology for determination of mannose-binding lectin haplogenotypes and roles of this receptor in the etiopathogenesis of oral disease
Authors

MOHLEROVÁ Nora MRÁZKOVÁ Jana ŠÍSTEK Petr LOCHMAN Jan IZAKOVIČOVÁ HOLLÁ Lydie BOŘILOVÁ LINHARTOVÁ Petra

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Mannose-binding lectin (MBL) plays an important role in innate immunity. This receptor recognizing molecular patterns on the surface of pathogens is studied and associated with a number of diseases of the oral cavity (recurrent aphthous stomatitis, periodontitis, oral lichen planus, tooth decay). The aim of this work was to design an effective methodology for the identification of functional polymorphisms in the MBL2 gene, whose allelic and genotypic combinations affect the expression of the MBL2 gene.
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