Publication details
Revoluce v imunoterapii nádorů: CAR-T lymfocyty
| Title in English | Revolution in tumor immunotherapy: CAR-T lymphocytes |
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| Authors | |
| Year of publication | 2019 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The development of molecular biological methods has enabled, among other things, genetic modification of human primary cells for treatment. The development of a method for modifying T lymphocytes using so-called chimeric antigen receptors (CAR) has revolutionized the cellular therapy of various tumor types. In this method, T lymphocytes are isolated from the patient's blood and genetically modified to stably express the CAR receptor. This receptor consists extracellularly of a binding portion of an antibody directed against a specific antigen expressed on the surface of tumor cells. The intracellular portion of the CAR receptor contains various signaling domains derived from T-cell receptor and costimulatory receptors. Thus, binding of the CAR receptor to a target tumor antigen results in T cell activation and specific lysis of tumor cells. |
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