Publication details

Vliv subkután­ně podávaného interferonu beta-1a na aktivitu onemocnění u pa­cientů s klinicky izolovaným syndromem - observační studie ATRACT

Title in English Effect of subcutaneously administered interferon beta-1a on disease activity in patients with clinically isolated syndrome - ATRACT observational study
Authors

MELUZINOVA E. TVAROH A. BLUDOVSKA M. PITHA J. VALIS M. MARES J. BENEŠOVÁ Yvonne MARTINKOVA A. DUFEK Michal HRADILEK P. AMPAPA R. GRUNERMELOVA M. BOZOVSKY T. ADAMKOVA J. ZIMOVA D.

Year of publication 2019
Type Article in Periodical
Magazine / Source Ceska a slovenska neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.14735/amcsnn2019442
Doi http://dx.doi.org/10.14735/amcsnn2019442
Keywords multiple sclerosis; clinically isolated syndrome; interferon beta-1a; treatment response; disease activity
Description Background: Several clinical studies have shown that early treatment of clinically isolated syndrome (CIS), can improve the course and prognosis of the disease. Patients and methods: ATRACT was an observational, non-interventional, prospective, non-comparative, non-randomized, single-arm, open-label, multicentre phase IV study, which primary aim was to investigate a relationship between clinical features of CIS and therapeutic response to 44 pg of subcutaneous interferon (IFN) beta-1a administered three times a week. A total number of 250 subjects aged 18 - 65 years, diagnosed with CB and treated with IFN beta-1a, were enrolled in the study. Patients were followed up for 24 months from baseline and during visits scheduled 6, 12, 18 and 24 months after the baseline visit. Data on the disability level (evaluated by Expanded Disability Status Scale [EDSS]), and number and time of relapses were collected. Results: The proportion of clinically stable subjects was 75.11% within the first year after the treatment initiation, and 59.11% at the end of the follow-up period. Throughout the 2 years, majority of subjects (85.45%) did not experience 3-month confirmed EDSS progression, and the proportion of relapse-free subjects was 62.67%. There was no significant difference in clinical activity between subgroups with mono- and polysymptomatic CB. Conclusion: IFN beta-1a treatment led to a stabilization of clinical activity in most subjects with CIS within 2 years. The clinical stabilization had not been affected by the clinical nature of CIS and the initial MRI finding.

You are running an old browser version. We recommend updating your browser to its latest version.

More info