Publication details

Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin

Authors

NEVÍDALOVÁ Hana MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2020
Type Article in Periodical
Magazine / Source Journa of Separation Science
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.1002/jssc.202000594
Doi http://dx.doi.org/10.1002/jssc.202000594
Keywords CE; Albumin; Drug
Description In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal analysis, and the obtained values of binding parameters were compared with the literature data. The affect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.
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