Publication details

Závažná hypernatremie u kojence s vývojovou vadou centrální nervové soustavy

Title in English Severe hypernatremia in an infant with a central nervous system developmental disorder
Authors

JABANDŽIEV Petr PECL Jakub JOUZA Martin ŠTARHA Jiří PAPEŽ Jan URÍK Milan SEEHOFNEROVÁ Anna HORÁK Ondřej

Year of publication 2020
Type Article in Periodical
Magazine / Source Pediatrie pro praxi
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.pediatriepropraxi.cz/artkey/ped-202004-0013_zavazna_hypernatremie_u_kojence_s_vyvojovou_vadou_centralni_nervove_soustavy.php
Doi http://dx.doi.org/10.36290/ped.2020.059
Keywords hypernatremia; polyuria; diabetes insipidus; holoprosencephaly
Description We present acase report of an infant with septooptic dysplasia variant (holoprosencephaly spectrum) with accidentally found severe hypernatremia. The case report points to the possibility of coincidence of hypopituitarism in patients with this form of forebrain malformation. Combined primary endocrine deficits in neonates and infants may result in derangement of body internal environment. Severe hypernatremia due to central diabetes insipidus is one of the potentially fatal complications requiring avery gradual, strictly controlled correction of the internal environment parameters. This is the only way to prevent serious neurological complications due to the rapidly changing internal environment.

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