Publication details

Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue

Authors

KUČERA Jan HORSKÁ Kateřina HRUŠKA Pavel KURUCZOVÁ Daniela MICALE Vincenzo RUDÁ Jana DOBROVOLNÁ Julie

Year of publication 2021
Type Article in Periodical
Magazine / Source Progress in Neuro-Psychopharmacology & Biological Psychiatry
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub
Doi http://dx.doi.org/10.1016/j.pnpbp.2020.110165
Keywords Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol
Description Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue.
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