Publication details

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal Δ9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

Title in English Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal ?9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
Authors

DI BARTOLOMEO Martina ŠTARK Tibor ORIANA MARIA Maurel IANNOTTI Fabio Arturo KUCHAR Martin RUDÁ Jana PISCITELLI Fabiana SAMUELE Laudani PEKAŘÍK Vladimír SALOMONE Salvatore AROSIO Beatrice MECHOULAM Raphael MACCARRONE Mauro DRAGO Filippo WOTJAK Carsten DI MARZO Vincenzo VISMARA Matteo DELL'OSSO Bernardo D'ADDARIO Claudio MICALE Vincenzo

Year of publication 2021
Type Article in Periodical
Magazine / Source PHARMACOLOGICAL RESEARCH
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub
Doi http://dx.doi.org/10.1016/j.phrs.2020.105357
Keywords Schizophrenia, THC, Cannabinoid CB1 receptor, Dopamine D2 Receptor, Cannabidiol, DNA methylation, Epigenetics
Description Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.
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