Publication details
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal Δ9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
Title in English | Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal ?9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease |
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Authors | |
Year of publication | 2021 |
Type | Article in Periodical |
Magazine / Source | PHARMACOLOGICAL RESEARCH |
MU Faculty or unit | |
Citation | |
Web | https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub |
Doi | http://dx.doi.org/10.1016/j.phrs.2020.105357 |
Keywords | Schizophrenia, THC, Cannabinoid CB1 receptor, Dopamine D2 Receptor, Cannabidiol, DNA methylation, Epigenetics |
Description | Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity. |
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