Publication details
Nejvýznamnější nežádoucí účinky neopioidních analgetik a jejich farmakologické mechanismy
| Title in English | The most significant side effects of non-opioid analgesics and their pharmacological mechanisms |
|---|---|
| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Neurologie v praxi |
| MU Faculty or unit | |
| Citation | |
| web | https://www.neurologiepropraxi.cz/artkey/neu-202006-0012_nejvyznamnejsi_nezadouci_ucinky_neopioidnich_analgetik_a_jejich_farmakologicke_mechanismy.php |
| Doi | https://doi.org/10.36290/neu.2020.108 |
| Keywords | non-steroidal anti-inflammatory drugs; cyclooxygenase; side effects |
| Description | Analgesics belong to the most commonly prescribed drugs. Non-opioid analgesics are drugs of various chemical origin that have analgesic, antipyretic and some of them also have anti-inflammatory and antiaggregation effect. They can be divided into analgesics - antipyretics and non-steroidal anti-inflammatory drugs. Inhibition of cyclooxygenase and thus influencing the formation of eicosanoids is a common mechanism of action, especially in nonsteroidal antiphlogistics. Both desirable therapeutic effects and side effects are associated with the influencing of eicosanoid production. |