Publication details

MONOLITHIC COLUMNS FOR SEPARATION OF LOW-MOLECULAR COMPOUNDS

Authors

STANKOVA M JANDERA P URBAN Jiří SKERIKOVA V

Year of publication 2012
Type Article in Proceedings
Citation
Keywords Organic polymer monoliths; Efficiency; Low-molecular compounds
Description Crosslinking monomers with various lengths of methylene or oxyethylene chains between two methacrylate units were applied for preparation of polymethacrylate monolithic columns suitable for isocratic separation of low-molecular compounds, using lauryl methacrylate as the functional monomer for reversed-phase chromatography. The crosslinking monomers included ethylene-, tetramethylene-, hexamethylene-, dioxyethylene-, trioxyethylene-, and tetraoxyethylene dimethacrylates. The replacement of generally used ethylene dimethacrylate as a crosslinking monomer by monomers with longer methylene and oxyethylene chain led to significant increase in the column efficiency. For example, a column prepared with tetraoxyethylene dimethacrylate shows the column efficiency of 71 000 theoretical plates per meter and offers fast isocratic separation of six low-molecular alkylbenzenes in 2 minutes. This confirms the significant effect of the length of the oxyethylene chain in the crosslinking monomer on the efficiency of polymethacrylate capillary columns.

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