Publication details

Significant mutation enrichment in inverted repeat sites of new SARS-CoV-2 strains

Authors

BARTAS Martin GOSWAMI Pratik LEXA Matej ČERVEŇ Jiří VOLNÁ Adriana FOJTA Miroslav BRAZDA Vaclav PEČINKA Petr

Year of publication 2021
Type Article in Periodical
Magazine / Source Briefings in Bioinformatics
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.1093/bib/bbab129
Doi http://dx.doi.org/10.1093/bib/bbab129
Keywords SARS-CoV-2; mutations; inverted repeats
Description In a recently published paper, we have found that SARS-CoV-2 hot-spot mutations are significantly associated with inverted repeat loci and CG dinucleotides (Goswami, Bartas et al., 2020). However, fast-spreading strains with new mutations (so-called mink farm mutations, England mutations, and Japan mutations) have been recently described. We used the new datasets to check the positioning of mutation sites in genomes of the new SARS-CoV-2 strains. Using an open-access Palindrome analyzer tool we found mutations in these new strains to be significantly enriched in inverted repeat loci.

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