Publication details
Protizánětlivý potenciál kompozitů kvasinkových glukanových částic a geranylovaného flavonoidu diplakonu
| Title in English | Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone |
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| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská farmacie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2020-3-10/protizanetlivy-potencial-kompozitu-kvasinkovych-glukanovych-castic-a-geranylovaneho-flavonoidu-diplakonu-123706 |
| Keywords | AP-1; Diplacone; Encapsulation; Glucan particles; Inflammation; NF-kB |
| Description | Geranylated flavanone diplacone is a flavanone isolated from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water. Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs). GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of Beta-(1->3)/Beta-(1->6) glucan mainly. The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone. The cell line THP1-XBlue™-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction. The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor kB (NF-kB) and activator protein 1 (AP-1). |