Publication details

Prehľad biorelevantných dynamických disolučných prístrojov

Title in English An Overview of Biorelevant Dynamic Dissolution Instruments
Authors

BÍLIK Tomáš STUPÁK Ivan VYSLOUŽIL Jakub ČULEN Martin DOHNAL Jiří

Year of publication 2021
Type Article in Periodical
Magazine / Source CHEMICKÉ LISTY
MU Faculty or unit

Faculty of Pharmacy

Citation
Web http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3953/3862
Keywords solid oral dosage forms; biorelevant dissolution test; in vitro gastrointestinal system
Description The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms.

You are running an old browser version. We recommend updating your browser to its latest version.

More info