Publication details

Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity

Investor logo
Investor logo
Authors

POLJAK Michal WOHLRABOVA Lucie PALAO UTIEL Eduardo NOCIAROVÁ Jela MISEK Jiri SLANINA Tomáš KLÁN Petr

Year of publication 2022
Type Article in Periodical
Magazine / Source Bulgarian Chemical Communications
MU Faculty or unit

Faculty of Science

Citation
Web https://www.scopus.com/record/display.uri?eid=2-s2.0-85131224229&origin=resultslist&sort=plf-f&src=s&st1=10.1039%2fd2cc02016e&sid=fb45a799d1eb2aeaaeb4725c07aa1af4&sot=b&sdt=b&sl=23&s=DOI%2810.1039%2fd2cc02016e%29&relpos=0&citeCnt=0&searchTerm=&featureTog
Doi http://dx.doi.org/10.1039/d2cc02016e
Keywords FLUORESCENT-PROBES; OXIDATIVE STRESS; HYDROGEN-SULFIDE; SE-BODIPY; CYCLE; SELENOXIDE; PROTEIN; REPAIR; ACID
Description Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is of great importance. Here, we introduce a series of sulfur- and selenium-substituted BODIPY derivatives as reversible redox sensors for ROS and enzymatic redox processes. Significant differences in emission maxima and fluorescence quantum yields between the reduced and oxidized forms make them excellent ratiometric turn-on/off probes. Installation of polar sulfonate groups improved their aqueous solubility while retaining their sensing properties, which allowed the probes to monitor the enzymatic activity of enantioselective methionine sulfoxide reductase.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info