Publication details

Jizvící pemfigoid s očním postižením

Title in English Mucous membrane pemphigoid with ocular involvement
Authors

JANÍČKOVÁ Lucia JEDLIČKOVÁ Hana RYBÁROVÁ Natália MICHALCOVÁ Lenka

Year of publication 2021
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Mucous membrane pemphigoid is a rare autoimmune bullous disease with an annual incidence of 1 per million. Clinical features include erosions with subsequent scarring, especially of the mucous membranes of the oral cavity, nose, eyes and genitals. Ocular pemphigoid is a severe type of scarring pemphigoid affecting the conjunctiva. Due to the rarity of the disease, low sensitivity of standard investigations (histology and immunofluorescence investigation of tissue and serum) and unavailability of serological testing of laminin 332 and alpha6beta4 integrin (ELISA only for BP antigens), in many cases it is not possible to make an unequivocal diagnosis. I. Department of Dermatovenerology is the ERN Reference Center specialized in diagnosis and treatment of autoimmune bullous diseases. We describe a group of patients with mucous membrane pemphigoid with ocular involvement treated at our clinic. We organized data with a focus on age, clinical features, investigations performed, disease course and management. This publication was funded by an internal grant provided by St. Anne´s University Hospital Brno

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