Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
|Year of publication
|Article in Periodical
|Magazine / Source
|Folia Mendeliana : supplementum ad Acta Musei Moraviae
|MU Faculty or unit
|Gregor Johann Mendel; oral microbiome; dental calculus; palaeoproteomics; palaeogenomics; periodontitis
|As part of the interdisciplinary research of abbot and founder of genetics, Gregor Johann Mendel, his dental calculus was sampled to gain insight into his health that could not be obtained by mere genome sequencing. A total of 469 proteins were found after filtering, including proteins related to immunity and oral health. Multiple oral species connected to dental pathology such as periodontitis were confirmed based on both DNA and proteins, originating from Porphyromonas gingivalis, Tannerella forsythia, or Treponema denticola. High abundance of Clostridiales DNA was confirmed, in agreement with mummification by saponification.