Publication details

Are there differences in EEG between epileptic patients with vagal nerve stimulation (VNS) and healthy controls?

Authors

DOLEŽALOVÁ Irena KORIŤÁKOVÁ Eva CHLADEK J. JURKOVÁ Tereza CHRASTINA Jan JURAK P. BRÁZDIL Milan

Year of publication 2022
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Background and aims: The presented work is based on the results of our published work, in which we focused on the VNS efficacy prediction in patients with drug-resistant epilepsy. We found that there are differences in power spectra between VNS responders and non-responders. We asked two more questions. Are there differences between the epileptic patients with VNS and healthy controls? Do the EEG power spectra in healthy controls resemble more responders or non-responders to VNS therapy? Methods: We identified retrospectively EEG recording in epileptic patients with VNS and in healthy controls. The epileptic patients were classified based on the VNS efficacy as responder and non-responders EEG was segmented into several time-intervals (resting-state, eyes-opening 1, resting state, photic stimulation, hyperventilation, eyes opening 2, resting state 3 and resting state) and frequency bands. Subsequently, we established relative EEG power spectra in pre-defined frequency bands and time-intervals. Results: We identified EEG in 56 healthy controls and in 60 epileptic patients with VNS (35 responders, 25 non-responders). When compared healthy controls and epileptic patients, we identified EEG power spectra differences in theta (eyes-opening 1, 2), alpha (eyes-opening 1,2) and beta frequency range (eyes-opening 1). When compared responders to VNS therapy and healthy controls, we found more significant differences than in non-responders.
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