Publication details

Stevens-Johnsonův syndrom a toxická epidermální nekrolýza z pohledu patologa

Title in English Stevens-Johnson syndrome and toxic epidermal necrolysis from pathologist’s point of view
Authors

STICOVÁ Eva KYCLOVÁ Jitka DŮRA Miroslav ŠTORK Jiří LIPOVÝ Břetislav

Year of publication 2023
Type Article in Periodical
Magazine / Source Cesko-Slovenska Patologie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2023-3-19/stevens-johnsonuv-syndrom-a-toxicka-epidermalni-nekrolyza-z-pohledu-patologa-135345
Keywords direct immunofluorescence; toxic epidermal necrolysis; Lyell syndrome; Stevens-Johnson syndrome; histopathological examination
Description Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell syndrome) are rare diseases characterized by rapid blistering followed by extensive skin and mucosal exfoliation and constitutional symptoms. In most cases, drugs are the main triggers, but the etiopathogenesis of the diseases is not fully understood. Lyell syndrome is associated with a high mortality rate, reported to be around 35%. Therefore, early diagnosis requiring close interdisciplinary cooperation is essential. The diagnosis based on the clinical picture and a detailed pharmacological history should be confirmed by histopathological examination of the skin specimen, including analysis by direct immunofluorescence.

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