Publication details
Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats
| Authors | |
|---|---|
| Year of publication | 1999 |
| Type | Article in Periodical |
| Magazine / Source | The Journal of Pharmacology and Exper. Therapeutics |
| MU Faculty or unit | |
| Citation | |
| Web | https://jpet.aspetjournals.org/content/291/1/239.long |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | Rats; methamphetamine; serotonin agonists; serotonin antagonists; serotonin uptake inhibitors; discriminative behaviour |
| Description | The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes. |
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