Publication details
Transplantace střevní mikrobioty - aktuální trendy a budoucnost
| Title in English | Fecal microbiota transplantation - current trends and future perspectives |
|---|---|
| Authors | |
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | Medicína pro praxi |
| MU Faculty or unit | |
| Citation | |
| web | Transplantace střevní mikrobioty - aktuální trendy a budoucnost |
| Doi | https://doi.org/10.36290/med.2025.014 |
| Keywords | dysbiosis; Clostridioides difficile infection; microbiota; fecal microbiota transplantation |
| Description | Disruption of the human microbial ecosystem represents a significant pathogenic factor of many diseases. The role of altered intestinal microbiota in the pathogenesis of recurrent Clostridium difficile colitis has been known for decades. Still, severe disruptions in the composition or function of the microbiota (we are speaking about dysbiosis) is nowadays also described in the pathogenesis of other pathological conditions. In this sense, the most commonly listed are idiopathic inflammatory bowel diseases, irritable bowel syndrome, type 2 diabetes mellitus, multiple sclerosis, Parkinson's disease, furthermore, for example, hepatic encephalopathy in patients with liver cirrhosis. We try to therapeutically intervene on the level of damaged intestinal microbiota in various ways. One very promising method seeks to restore natural microbial homeostasis in the colon using stool from a healthy donor, which is transferred into the digestive tract of the patient. For us, this method became commonly known as "fecal bacteriotherapy". The international literature typically uses the term "Fecal Microbiota Transplantation" or by the abbreviation FMT. |