Publication details
Terapeutické monitorování léčiv - cesta k efektivnější antibiotické terapii. Praktické zkušenosti Fakultní nemocnice
| Title in English | Therapeutic drug monitoring - a path to more effective antibiotic therapy |
|---|---|
| Authors | |
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | Anesteziologie a intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| web | https://aimjournal.cz/artkey/aim-202502-0003_therapeutic-drug-monitoring-a-path-to-more-effective-antibiotic-therapy.php |
| Doi | https://doi.org/10.36290/aim.2025.015 |
| Keywords | therapeutic drug monitoring (TDM); antibiotic therapy; piperacillin/tazobactam; meropenem; cefepime; linezolid |
| Attached files | |
| Description | Therapeutic drug monitoring (TDM) is a key tool in optimizing antibiotic therapy in critically ill patients. The variability of pharmacokinetics and pharmacodynamics (PK/PD) in this population often requires an individualized approach that goes beyond standard dosing schedules. Early implementation of TDM, especially during the first 48 hours of treatment, is essential to achieve target therapeutic antibiotic concentrations. The correct administration strategy, using prolonged or continuous infusions of the administered antibiotics, plays a significant role in achieving optimal PK/PD parameters. At our institution, we have observed a high variability in the concentrations achieved for ß-lactam antibiotics over the years, which supports the wider implementation of TDM in routine clinical practice. |
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