Publication details
Drug self-administration behavior in rats is altered by sex, models of psychopathology and treatment
| Authors | |
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| Year of publication | 2026 |
| Type | Requested lectures |
| MU Faculty or unit | |
| Citation | |
| Description | The talk summarized preclinical evidence showing how sex differences, comorbid psychopathology, and pharmacological interventions modulate drug self-administration and drug-seeking behavior in rodents. Using established animal models of substance use disorder comorbid with depression, schizophrenia, and autism spectrum disorders, it highlights substance-specific alterations in intake, seeking, extinction, and locomotor responses. The work further evaluates the therapeutic potential of glutamatergic (AMPA/kainate) antagonists and GLP-1 receptor agonists, emphasizing their substance- and protocol-dependent effects. Overall, the findings underscore the complexity of dual-diagnosis models and point to key methodological and translational challenges in developing effective treatments for substance use disorders. |
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