Publication details
Synthesis of valproic acid for medicinal chemistry practical classes
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | CHEMISTRY TEACHER INTERNATIONAL |
| MU Faculty or unit | |
| Citation | |
| web | De Gruyter Brill |
| Doi | https://doi.org/10.1515/cti-2025-0028 |
| Keywords | medicinal chemistry; practical classes; active pharmaceutical ingredient (API) synthesis; valproic acid |
| Description | Medicinal (or also Pharmaceutical) Chemistry practical classes are intended to familiarize students who have already passed Inorganic and Organic Chemistry Courses in the first or the second year of a Faculty of Pharmacy with real syntheses of medicines that are used in the practice. The selection of practical tasks is limited by the time reserved for each practical lesson in which at least one step of a multi-step synthesis must be done. This fact pushes us to optimize individual synthesis steps to shorten them as much as possible, but with acceptable yields. Valproic acid, 2-propylpentanoic acid, is a drug approved originally as an antiepileptic but is now used as a co-analgesic and in various neurology indications. Our synthesis comes from the classical malonate synthesis but is newly optimized to be managed during three practical lessons. |