Publication details
Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke
| Title in English | Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic strokeFibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke |
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| Authors | |
| Year of publication | 2026 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Ceska a slovenska neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| web | STROKE |
| Doi | https://doi.org/10.48095/cccsnn202663 |
| Keywords | stroke; ischemia; sis; fibrinogen; intracranial hemorrhage; parenchymal hematoma |
| Description | Backgroundandobjective:Although intravenous thrombolysis(IVT) isa recommended recanalization therapy for ischemic stroke, it is associated with a risk of symptomatic intracranial hemorrhage. This academic clinical study aims to evaluate the relationship between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of intracranial hemorrhage, specifically parenchymal hematoma, which is the most clinically significant type of intracranial hemorrhage. Methods: Seven primary stroke centers and comprehensive stroke centers in the Czech Republic will be involved in the multicenter retrospective study. The estimated total number of patients enrolled in the observation and control groups is 300, with defined entry parameters maintained. The parameters monitored include personal and pharmacological history, laboratory parameters, neurological findings, and imaging results. Results: The study will evaluate the degree of association between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of parenchymal hematoma. Conclusion: Evidence of an association between the development of parenchymal hematoma and a decrease in fibrinogen levels in patients with ischemic stroke treated with IVT may be used to design an interventional study with fibrinogen replacement to prevent bleeding. |