Publication details
Effect of a high-gluten diet on the intestinal barrier in an animal model
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| Year of publication | 2024 |
| Type | Conference abstract |
| Citation | |
| Description | Poster presented at the 20th International Celiac Disease Symposium ICDS in Sheffield, UK. In recent years, the incidence of Celiac disease has been rising, even though the prevalence of the risk genotype in the population remains constant. Environmental factors such as intestinal dysbiosis, viral diseases, and changes in dietary habits like the "Western diet" contribute to the increased incidence of celiac disease. These factors impact the intestinal barrier and, combined with increased gluten consumption, can lead to the breakdown of oral tolerance. The only treatment is a gluten-free diet based on strictly avoiding wheat, rye, and barley. In the past, oats were also included in this list of grains, but their role in a gluten-free diet is now widely debated. Unlike wheat, oats have a lower content of prolamins (10-15% compared to 80-85%), and their sequences contain fewer proline and glutamine amino acids. A previous study indicated that the consumption of pure oats led to the development of villous atrophy in some patients with celiac disease. Today, however, the prevailing opinion is that uncontaminated oats are safe for nearly all patients with celiac disease, a small percentage may be sensitive to certain oat varieties and should be monitored. Certain guidelines recommend starting a gluten-free diet (GFD) without oats and introducing them later. To understand the impact of gluten, gliadins, and avenins, mice were selected as a model for a healthy organism. The mice were fed a diet containing various prolamins for five weeks, and at the end of the experiment, their effects on the overall condition of the animals were compared. |