Publication details
Structure of the LE3 phage infecting Leptospira biflexa
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| Year of publication | 2026 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Phage therapy based on lytic bacteriophages complements conventional treatment approaches to combat increasing antimicrobial resistance. Reduced antibiotic susceptibility has also been reported in Leptospira, a genus of Gram-negative spirochetes responsible for leptospirosis in humans and animals. Leptospira biflexa serves as a non-pathogenic bacterial model to study leptospiral biology and phage infection. Bacteriophage LE3 is one of the few described lytic phages infecting L. biflexa. In our study, we determined the structure of phage LE3 using cryo-electron microscopy. Furthermore, the thin, electron-transparent morphology of L. biflexa allowed direct visualization of phage particles within cells and facilitated structural analysis of phage assembly intermediates. |
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