Interakce mutace M235T genu pro angiotenzinogen a mutace Taq1 8000 v genu pro endotelin-1 při vzniku esenciální hypertenze

• Title in English: Interaction of Mutations M?235T ATG and Taq1 8,000 in the Gene for Endothelin-1 at the Onset of Essential Hypertension
• Authors: VAŠKŮ Anna; SOUČEK Miroslav; ZNOJIL Vladimír; KUHROVÁ Viera; TSCHÖPLOVÁ Svatava; VÁCHA Jiří
• Year of publication: 2000
• Type: Article in Periodical
• Magazine / Source: Časopis lékařů českých
• MU Faculty or unit: Faculty of Medicine
• Field: Cardiovascular diseases incl. cardiosurgery
• Description: The aim of the study was to prove the existence of double genotype coincidence of polymorphic candidate genes between normotensive and hypertensive subjects. A Czech population sample (398 subjects, 192 normotensives and 206 hypertensives) was genotyped at angiotensinogen (M235T) and endothelin-1 (G8002A ET-1)genes using PCR method. We proved interaction of two polymorphic variants of both genes in essential hypertension-the decrease of MT heterozygotes in (--)homozygotes (P=0.0025) and the increase of the alele (-) in MM homozygotes(P=0.0034).

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