Publication details

Changes of CYP2D6 acitivity in rats after drugs of abuse medication

Authors

ZELENKOVÁ Olga HADAŠOVÁ Eva TOMANDLOVÁ Marie NOVÁKOVÁ Jana VINKLEROVÁ Jana

Year of publication 2001
Type Article in Periodical
Magazine / Source Homeostasis
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords CYP2D6; drugs of abuse; metabolism; inhibition
Description The aim of the study was to establish the influence of long term medication of metamphetamine on the cytoshrome P450 2D1/6 activity in rats in "i.v. self-administration" model.Insignificant decrease in the enzyme activity was recorded.
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