Publication details

The role of the serotonergic system in experimental drug dependence

Authors

NOVÁKOVÁ Jana

Year of publication 2002
Type Article in Periodical
Magazine / Source Scripta medica
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords 5-HT receptor agonists; 5-HT receptor antagonists; diazepam; methamphetamine; "i.v. drug self-administration"; "drug discrimination"; agonistic behaviour;mice;rats
Description Thu study presents the utilization of behavioural experimental models to assess the role of serotonin neurotransmitter brain system in withdrawal signs occurred after ending of chronic diazepam treatment, and in rat methamphetamine dependence. The results referred bring the evidence about a possible preventive action of serotonergics from the occurrence of withdrawal signs while pre-treated prior to diazepam repeated administration withdrawal.
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