Publication details
Effects of CB2receptor agonist palmitoylethanolamide and CB2receptor antagonist AM 630 on leukocyte phagocytic activity in mice
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | cannabinoids; palmitoylethanolamide; AM 630; leukocyte phagocytosis; chemiluminescence; mice |
| Description | The cannabinoids are involved in regulation of immune function. This action can be mediated either through cannabinoid receptors which subtypes CB1 and CB2 have been identified on leukocytes, or by non-receptor mechanism not clearly understood yet. The present study investigated th influence of the CB2 receptor agonist palmitoylethanolamide and the CB2 receptor antagonist AM 630 on the cellular immune function on leukocyte phagocytosis. Phagocytic activity of mouse leukocytes was measured in chemiluminescence (CL) assay using zymosan induction of phagocytosis and luminol potentiated of CL in vitro. |
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