Publication details

Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

Authors

NAVRÁTILOVÁ Jarmila ŠEVČÍKOVÁ Sabina ŠMARDA Jan

Year of publication 2002
Type Article in Proceedings
Conference Cells IV
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords p53; Myb; differentiation; proliferation; roscovitine
Description BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.
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