A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

• Authors: MCGREGOR Tracey D.; HEGMANS Alexander; KAŠPÁRKOVÁ Jana; NEPLECHOVÁ Kamila; NOVÁKOVÁ Olga; PEŇÁZOVÁ Hana; VRÁNA Oldřich; BRABEC Viktor; FARRELL Nicholas
• Year of publication: 2002
• Type: Article in Periodical
• Magazine / Source: Journal of Biological Inorganic Chemistry
• MU Faculty or unit: Faculty of Science
• Web: http://link.springer.de/link/service/journals/00775/tocs/t2007004.htm
• Field: Biophysics
• Keywords: unwinding; dinuclear platinum; hydrogen bonding; cross-links
• Description: The dNA binding profiles of three bisplatinum polyamine-linked compounds were compared with that of antitumor efficient trisplatinum compound BBR3464. It was found that their binding manner is similar.