A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

• Autoři: MCGREGOR Tracey D.; HEGMANS Alexander; KAŠPÁRKOVÁ Jana; NEPLECHOVÁ Kamila; NOVÁKOVÁ Olga; PEŇÁZOVÁ Hana; VRÁNA Oldřich; BRABEC Viktor; FARRELL Nicholas
• Rok publikování: 2002
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Journal of Biological Inorganic Chemistry
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://link.springer.de/link/service/journals/00775/tocs/t2007004.htm
• Obor: Biofyzika
• Klíčová slova: unwinding; dinuclear platinum; hydrogen bonding; cross-links
• Popis: The dNA binding profiles of three bisplatinum polyamine-linked compounds were compared with that of antitumor efficient trisplatinum compound BBR3464. It was found that their binding manner is similar.