Publication details
Use of osmium tetroxide-bipyridine reagent in MALDI-TOF MS analysis of peptides including [Gly14]-humanin derivatives
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Biologicky aktivní peptidy VIII. |
| MU Faculty or unit | |
| Citation | |
| Field | Analytic chemistry |
| Keywords | osmium tetroxide; bipyridine; humanin; MALDI-TOF MS; PSD |
| Description | Osmium tetroxide-bipyridine (Os,bipy) is a reagent which has successfully been applied in analysis of DNA and it has been recently proposed as a suitable probe for peptide derivatization because of its ability to form stable complex with tryptophan residues. In this work the reaction of Os,bipy with peptides including humanin derivates was studied using Matrix Assisted Laser Desorption-Ionisation - Time of Flight Mass Spectrometry (MALDI-TOF MS). |