Publication details
Mapování vazebné nerovnováhy SNP v RAGE a GLY1 genech a identifikace haplotypového markeru diabetické nefropatie u T2DM v České populaci
| Title in English | Mapping of linkage disequilibrium of SNPs in the RAGE and GLY1 genes and identification of haplotype disease marker of diabetic nephropathy in T2DM in Czech population |
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| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Diabetologie, metabolismus, endokrinologie, výživa |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | diabetes; complications; nephropathy; association; RAGE; glyoxalasis |
| Description | We conclude that RAGE haplotype consisting of -429C/-374T/+2184G alleles can be regarded one of genetic risk factors of susceptibility and progression of diabetic nephropathy (DN). Character of asociation, frequency of risk haplotype and gain-of-function type of effect are in agreement with the results of segregation analyses of DN in T2DM. |
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