Publication details

The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice

Authors

LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2004
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; JWH-015; locomotor activity; mice
Description The present study was designed to test a possible effect of selective agonist at cannabinoid CB2 receptor - JWH 015 (JWH) on behavioural sensitization to MET. Behavioural changes were measured in the open field test. MET and combined MET+JWH pretreatments were administered for 7 days to the mice at the doses of 2.5 mg/kg/day and 5 mg/kg/ day, respectively. On the day 8 all mice were given a "challenge dose" of MET 2.5 mg/kg to check a development of sensitization phenomenon. The sensitization to MET has not been altered in the case of use of JWH in the pretreatment.
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