Publication details
Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Fundamental & Clinical Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression |
| Description | The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders. |
| Related projects: |